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In an open-label phase II trial, curcumin treatment (8 g/day) in combination with the anticancer drug gemcitabine was associated with severe abdominal pain in 7 out of 17 patients with advanced pancreatic cancer, leading to the treatment being discontinued in five patients while curcumin dosage was reduced to 4 g/day in two patients (79)

MOTS-C: The Energy Reboot Improves insulin sensitivity and metabolism

Discontinuation Trends and Persistence Patterns Despite the clinical benefits of GLP-1 receptor agonists, discontinuation remains a challenge

The right approach for them

Ozempic and Mounjaro, for example, are approved to treat type 2 diabetes and are widely prescribed off-label for weight management