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4 Hydration Staying well hydrated can help promote healthy digestion and reduce the chance of mistaking thirst for hunger

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While nausea, vomiting, and diarrhea are the most commonly reported gastrointestinal adverse effects with GLP-1-based therapies (occurring in 15-40% of patients depending on the agent and dose), FDA prescribing information for several of these medications does list dyspepsia (indigestion) and, in some cases, gastroesophageal reflux disease (GERD) as reported adverse reactions

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and A 2023 publication that used a sample of 16 million patients concluded GLP-1 drugs are associated with a significantly increased risk of bowel obstruction and stomach paralysis