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Retatrutide research has made interesting headway here, too, finding that the combined GLP-1/GIP agonism strongly impacts the satiety centers in the brainstem and hypothalamus

There is a theoretical increased risk of medullary thyroid cancers, but its not clear how likely this is to actually happen in people, says Fishman, who along with Vash stresses that the link has only ever been studied in animals

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[1] NAD+ also declines with age