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Uterotubal dysperistalsis, a dysfunction in tubal motility, may further disturb gamete and embryo transport ( Clinically, surgical laparoscopy aims to restore normal pelvic anatomy, though its benefit is most evident in minimal/mild disease

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Age-related muscle loss (the progressive loss of skeletal muscle mass and strength) may increase the risk of falls and has been associated with increased mortality (Clynes, Calcif Tissue Int 2015)

65 Despite efforts have been made to repair mtDNA with various mechanisms, the mutation rate of mtDNA remains higher than nuclear DNA

As a result, our review calls upon more attention to personalized approaches in characterization of individual thiamine homeostasis, based on the knowledge of the thiamine-dependent proteins and their tissue-specific features and functions