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Factors such as initial B12 levels, underlying medical conditions, certain medications, advanced age, and injection frequency can affect the absorption and utilization of B12, possibly shortening the duration of action
The main additional side effects come from injection site reactions, which remain mild and transient for most users
Functional improvements generally become noticeable during weeks 2 to 4
women who are pregnant or may become pregnant must not handle crushed or broken tablets
Clinical Evidence 2026 Update: Phase 3 TRIUMPH Data In December 2025, Eli Lilly reported the first successful Phase 3 readout for retatrutide (LY3437943) from the TRIUMPH-4 trial
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