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Semaglutide for Weight Loss: What the SURMOUNT-5 Results Mean for Northwest Louisiana Patients For the first time, a major clinical trial put tirzepatide (Mounjaro/Zepbound) and semaglutide (Ozempic/Wegovy) head to head in people with obesity who do not have diabetes, and the results landed in the New England Journal of Medicine in May 2025.[1] The short answer: tirzepatide produced significantly more weight loss

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In overweight adults with high blood pressure, diabetes, or high cholesterol, semaglutide injection (Wegovy) is used in conjunction with a low-calorie, low-fat diet and exercise program to lose weight