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reported that metformin regulates ferroptosis through the SIRT3/AMPK/mTOR pathway to improve weight, metabolic disorders, and ovarian dysfunction in PCOS mice (173)

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Glutathione depletion is an active research model in cell biology, with studies using GSH-depleting agents (such as buthionine sulfoximine or diethyl maleate) to examine the cellular consequences of oxidative stress

So, when your bodys GSH levels are depleted, youre essentially losing a key defense mechanism against these damaging processes

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