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Therapeutic drug monitoring in oncology: international association of therapeutic drug monitoring and clinical toxicology consensus guidelines for Imatinib therapy

24, 2026 at 8:00 AM CDT | Operation Fill A Backpack Updated: Jul

Koufoglou, E., Kourlaba, G., & Michos, A

When exogenous glutamine is depleted, AML cells significantly upregulate the expression of key SSP enzymes such as PHGDH, compensating for metabolic deficits by enhancing de novo serine synthesis to sustain cell survival and proliferation ( Research has identified that N-acetyltransferase 10 (NAT10)-mediated RNA acetylation (ac4C) promotes the uptake of exogenous serine by AML cells through enhancing the translation of the serine transporter SLC1A4