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Microglia are initially activated to stage 1 DAM, which are characterized by a downregulation of homeostatic microglial genes including p2ry12 and cx3cr1 , and an upregulation of genes including trem2 , tyrobp and apoe

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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, while metformin belongs to a class of medications called biguanides

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