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Patients who rush the titration or start at higher doses experience more severe side effects and higher discontinuation rates

J Physiol (2001) 531(Pt 3):58595.10.1111/j.1469-7793.2001.0585h.x 138 DuchmanSMRyanAJSchedlHPSummersRWBleilerTLGisolfiCV

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However, the jump from the first-month introductory price to the ongoing rate represents a 67 percent increase for semaglutide and a 43 percent increase for tirzepatide, something patients should budget for from the start

The fed-batch culture was performed in a 5-L bioreactor (NC-Bio, Shanghai, China) with the initial working volume of 2.5 L