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Subgroup analyses evaluated four key factors: administration route efficacy, daily dosage, age group and clinical conditions that may affect vitamin B12 metabolism (e.g., underlying pathology)
EN-RAGE [S100A12] was the only protein significantly associated with MACE after correction for multiple testing (hazard ratio (HR) per doubling of protein, 95% confidence interval: 1.30 [1.13-1.51], p FDR = 0.019)
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