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Although all unimolecular triple agonists in phase 2 trials for obesity are GLP1/GIP/GCG triple agonists, there is an ongoing phase 2 clinical trial of bioglutide, an oral insulin-like-growth factor-1 (IGF-1)/GLP-1/GIP/GCG quadruple agonist (NCT06564753) for individuals with obesity, which is also being trialled in combination with tirzepatide (NCT06643728)

Some reports required hospitalization

By understanding how the activity and secretion of these molecules can lead to metabolic diseases it may be possible to identify new and more efficient treatments, offering alternative paths for more effective therapies

Inadequate protein intake, reduced physical activity, and dehydration may also contribute

Method and frequency of cannabis use : Different consumption methods (smoking, vaping, edibles) carry different risks