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We next examined the p K a values of the five cysteines: C8, C23, C26, C79, and C83, as cysteine thiol deprotonation is a critical step for subsequent glutathionylation or oxidation by H 2 O 2 32

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However, the major enzymes of the fatty acid biosynthetic pathway, such as acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), are expressed in neuronal regions of the hypothalamus that are involved in energy homeostasis