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These findings suggest that certain cytokines might exert positive or negative effects on different tissues, suggesting that tissue-specific targeted therapy is an essential strategy to protect other normal tissues, such as the ovary, from NRTP-induced damage

However, letrozole, anastrozole, and exemestane are newer-generation AIs that dominate the drug category

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More studies are needed to better understand the role of FOXO in the pathogenesis of neurodegenerative diseases and its potential as a therapeutic target for PD treatment