Clinically, this potent effect is demonstrated by agents like semaglutide, which, in phase 2 trials, achieved MASH resolution without worsening fibrosis in a significant percentage of patients (Newsome et al., 2021
Before starting GLP-1 therapy , patients should discuss their complete medical history with their healthcare provider, including the duration and stability of their Hashimoto's disease, current levothyroxine dose, most recent thyroid function tests, and any family history of thyroid cancer or MEN 2 syndrome
A randomised trial found semaglutide reduced drinking in people with alcohol use disorder
More direct evidence for GLP-1 modulating dopamine transmission comes from a study showing that a GLP-1 agonist also reduced phasic dopamine response in the VTA in rats (Konanur et al., 2020)
If you're taking tirzepatide, consider a daily multivitamin containing at least 18 mg of iron (for women under 50) and 1000 mg of elemental calcium with vitamin D3