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preparation of compound 4: after being activated, the compound 3 and the amino at the end position of Arg34GLP-1 (9-37) in the compound 2 are subjected to acylation coupling reaction under the action of a condensation reagent and alkali to obtain a compound 4

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A 2025 systematic review published in PMC ( Hair Loss Associated With GLP-1 Receptor Agonist Use ) found that three studies reported significant hair regrowth with subcutaneous tirzepatide, while two others documented hair loss as an adverse event

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