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Ahlqvist E, Storm P, Krjmki A, et al

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Linking ERAD to lipid homeostasis: bidirectional communication between proteotoxicity and lipotoxicity ERAD functions as a posttranslational feedback regulator of lipid homeostasis during metabolic and environmental fluctuations

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The inflammatory microenvironment reduces the glutamate uptake, inducing accumulation of this excitatory amino acid and excitotoxic neurodegeneration