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By Lana Pine | Published on February 12, 2025 5 min read Over nine weeks, individuals who took once-weekly low-dose semaglutide a glucagon-like peptide 1 (GLP-1) receptor agonist often used for diabetes and weight loss drank less alcohol in a lab test, had lower alcohol cravings and smoked fewer cigarettes (if they were smokers)

It is a synthetic fragment of human growth hormone (amino acids 176-191), studied in research settings for its proposed role in fat metabolism

As blood levels build over weeks and months, different mechanisms come online at different times, which is why libido changes rarely follow a straight line in either direction

Adequate testosterone levels support muscle protein synthesis, meaning the body efficiently uses dietary protein to build and maintain lean tissue

These small changes, combined with guidance from a healthcare professional, can make managing side effects much easier