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Scott Isaacs, MD, FACP, FACEs Post Reduced-frequency GLP-1 as a maintenance strategy: in this case series, patients who tapered from weekly semaglutide/tirzepatide to less frequent dosing maintained weight loss, body composition, and metabolic syndrome gains, supporting structured de-escalation to lower burden without sacrificing efficacy

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GLP1 receptors exist in areas of the brain involved in reward and addictive behaviors, which may explain why many patients naturally drink less during treatment