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Side Effects: Long-term use can sometimes cause side effects that outweigh the benefits, such as gastrointestinal discomfort from orlistat or nausea from semaglutide

Interestingly, -syn can also impair mitochondrial function by reducing the expression of peroxisome proliferator-activated receptor gamma coactivator 1- (PGC1) and related target genes (Wilkaniec et al., 2021)

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The most common side effects are gastrointestinal and tend to improve after the first few weeks: Nausea, vomiting, or diarrhea (most common, especially early on) Constipation or stomach discomfort Reduced appetite Less common but serious side effects include pancreatitis, gallbladder issues, and low blood sugar particularly in patients taking diabetes medications