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This is the first step toward developing that knowledge, which will require large-scale, carefully controlled clinical trials. Huda Akil, Ph.D., the co-director and research professor at the Molecular and Behavioral Neuroscience Institute (MBNI) at the University of Michigan, tells GEN that severe, untreatable depression is remarkably difficult to unpack biologically with multiple paths to becoming depressed (genetic, development, metabolic, social). Because of this complexity, one treatment will not work for everyone. In addition to finding that patients with MDD have less LAC in their blood, the researchers were able to identify subtypes of patient populations based on their LAC levels

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352 Macrophages, which have antigen-presenting and phagocytic properties, play a key role in RA synovitis

JAMA 318 (15), 14601470