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In the kidneys, GPER expression is closely related to the reabsorption and excretion of calcium, and studies have shown that GPER activation can promote the reabsorption of calcium in renal tubules, thus maintaining blood calcium levels [134]

The authors noted that results from more recent studies were less positive than those from earlier studies, and concluded that routine clinical use of ALCAR to treat dementia signs and symptoms was not justified [15]

Separate studies demonstrated anti-anxiety effects in rats at remarkably low doses (0.5 mg/kg), with effects appearing within 12 minutes and including increased exploration of open and lighted spaces, a standard measure of reduced anxiety in rodent models

2008 Nov;54(11):1770-9

Cerebrolysin has a documented safety record from decades of clinical application in Europe and Asia