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DIRKO, double incretin receptor knockout

Participants who received the highest dose of orforglipron, 36 milligrams, lost 11.2% of their body weight - about 25 pounds on average - over more than 16 months

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Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion

During the fifth voting round, a final questionnaire with updated grading for the seven recommendations was disseminated to the group, and 100% consensus was achieved with 16 out of 16 questionnaires returned (Box 1)