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In the presence of GSH, GPX4 continuously reduce PLOOHs, and if GSH depletion or GPX4 inactivation, intracellular ferrous ions induce ferroptosis by breaking down PLOOHs to cause lipid peroxidation (Ursini and Maiorino, 2020)

Furthermore, advanced pharmacological research indicates that NAC is transformed into hydrogen sulfide (H2S) inside the mitochondria

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