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Efficacy: What the Head-to-Head Trial Showed In the head-to-head 72-week SURMOUNT-5 trial of 751 adults with obesity without diabetes, tirzepatide reduced body weight by an average of about 20.2% versus 13.7% for semaglutide

The role of adipose tissue and adipokines in obesity-related inflammatory diseases

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Severe deficiency : Weekly or biweekly injections may initially be required to correct anemia and neurological symptoms

These predispositions may help contextualize why you experience faster or slower early appetite suppression, though individual response involves many factors beyond genetics alone