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The cataplerotic reactions that involve conversion of PEP to pyruvate in the cytosol then pyruvate to oxaloacetate (OAA) then OAA to aspartate in the mitochondria then aspartate back to OAA in the cytosol and OAA back to PEP constitute what is referred to as pyruvate cycling

Still, Nrf2-deficient mice display age-dependent cardiomyopathy (87)

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Conclusions The engineered strains harbouring three GSH pathways displayed higher GSH producing capacity than those with individually modulated pathways

The Journal of Pharmacology and Experimental Therapeutics