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Intracellularly, GSH is maintained in its thiol-reduced form by NADPH-dependent enzymes (glutathione disulfide bond (GSSG) reductase)

population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

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Notably, the hepsin / mice exhibited a more pronounced increase in ROS levels after thioacetamide treatment compared with wild-type mice, which aligned with our hypothesis that hepsin / mice experience heightened ROS stress in the early stages of APAP exposure due to their elevated expression of GJ proteins (Fig

[24] When paracetamol is taken in large quantities, a toxic minor metabolite called N -acetyl- p -benzoquinone imine (NAPQI) accumulates within the body