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Semaglutide can reduce visceral fat volume by 20-30% in some patients while total body weight decreases by only 5-10%

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The SURPASS clinical trial program demonstrated that tirzepatide at its highest dose (15 mg weekly) produced average weight loss of 20-25% of body weight, significantly exceeding the results seen with GLP-1 only agonists

Some TRICARE plans, such as TRICARE For Life, no longer cover weight loss drugs as of August 2025