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In conclusion, LDHB silencing results in decreased viability and colony formation capacity in cancer cell lines from different genetic backgrounds and tissues of origin and is associated with increased lipid peroxidation, particularly mitochondrial lipid peroxidation, accompanied by changes in mitochondrial morphology, all characteristics associated with ferroptosis

Acute injuries may respond well to 6-8 week intensive protocols, while chronic conditions or post-surgical recovery might benefit from 10-12 week courses

All samples were examined under a laser scanning confocal microscope