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Studies in both humans and animals have shown that carnitine supplementation resulted in an improvement of glucose tolerance, in particular during insulin-resistant states

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Avoiding Freeze-Thaw Cycles Repeated freezing and thawing of the reconstituted solution can cause aggregation or potency loss

And metabolic impact analysis indicated that treatment with L-carnitine combined with trimetazidine can perturb the metabolism of amino acids, branched-chain amino acids, carbohydrates, and TCA intermediates (Figure 7B)

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