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Apart from its cardiovascular benefits,85 it plays an integral role in a cellular pathway that produces NAD+, which helps sustain mitochondrial health and lowers your risk of age-related diseases.86 87 A 300mg dose is considered to be a clinically relevant amount.88 PQQ (10mg): Human studies on PQQ have yielded optimistic implications for cognitive health in around 20mg doses.89 90 IM8s dose falls short