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This functional approach is centered on the premise that a breakdown of the intestinal mucosa caused by the chronic ingestion of processed foods, food- and water-based toxins, and the use of common over-the-counter drugs, such as NSAIDs, can lead to a hyperpermeable intestinal mucosa or leaky gut syndrome. This intestinal hyperpermeablility can result in the intestinal mucosa failing to act as a selective barrier, thereby allowing food toxins and partially digested food proteins to cross through the intestinal mucosa into the systemic blood supply

JACC Clin Electrophysiol 4(5):569579 George Jr AL (2005) Inherited disorders of voltage-gated sodium channels