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Interestingly, in chronically insulin treated 3T3-L1 cells and fat explants from insulin resistant mice, only insulin-stimulated glucose uptake is decreased while insulin suppression of lipolysis is intact (121), effects which are explained by selective insulin resistance in adipocytes

The Fenton reaction, which requires hydrogen peroxide (H 2 O 2 ) and ferrous iron (Fe 2+ ), generates ROS

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