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354 In addition, amitriptyline can increase the expression of Cx43 to promote gap junction intercellular communication (GJIC) between astrocytes, thereby relieving depressive symptoms

Carnosine is synthesized from BA and L-histidine in a reaction catalyzed by the non-specific enzyme carnosine synthase ( CARNS ), an enzyme located in skeletal muscle ( m , 1.02.3 mM) for carnosine synthase ( 1 ww) ( 1 ww) ( m (16.8 M) for carnosine synthase ( Carnosinase is a hydrolytic enzyme found in serum and tissue (Figure 1)

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