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Matrix metalloproteinase-9 activation in hyperhomocysteinemic rats is triggered by the opening of the mitochondrial permeability transition pore and antagonism of the N-methyl-D-aspartate receptor-1 (NMDA-R1), resulting in myocyte dysfunction due to elevated calcium overload and oxidative stress [40]

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The most commonly prescribed medications in this category include semaglutide (marketed as Wegovy for weight loss and Ozempic for diabetes) and tirzepatide (marketed as Mounjaro for type 2 diabetes and Zepbound for chronic weight management)