The activity index (AI) calculated by qualified gastroenterologist for UC was expressed as follows: AI = 60 x blood stool + 13 x bowel movements + 0.5 x erythrocyte sedimentation rate - 4 x haemoglobin - 15 x albumin + 200
The practical response is straightforward
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However, these two natural GLP-1R agonists are rapidly digested by the enzyme DPP-4 and cleared by the kidneys within 1-2 minutes, making them unsuitable for direct therapeutic use