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Description

Thyroid C-Cell Tumors: In mice and rats, semaglutide (the active ingredient in Wegovy, Ozempic, and Rybelsus) caused an increase in thyroid C-cell tumors, including medullary thyroid carcinoma (MTC)

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Hydration is critically important when experiencing diarrhea to prevent dehydration and electrolyte imbalances

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Maintaining patients at a given dose for an additional four weeks before escalation may be appropriate if gastrointestinal symptoms are difficult to characterize

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Although there is evidence that DPP-4 inhibitors confer cardiovascular safety and renoprotection, the potential risks of hospitalization for heart failure and acute pancreatitis are disadvantages to their use as add-on therapy

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The anti-inflammation effect of GLP-1RAs is shown in Figure 4

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