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Diabetic nephropathy Patients with poorly controlled type 1 diabetes mellitus (T1DM) present with markedly enhanced pituitary GH-secretion rates, probably related to decreased hypothalamic somatostatin tone and exaggerated GH-responses to physiological and pharmacological stimuli [186, 187]

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Together with the fact that T4C is the most abundant 2-( R )-thiazolidine-4-carboxylic acid, this finding suggests that T4C is most immediately accessible and decomposed under l-cysteine deprivation