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Transl Psychiatry 16 , 194 (2026)

being important mediators in the main functions of the keratinocyte: maintenance of the skin barrier function, interaction with the skin microbiome and triggering the immune response, including the recruitment of inflammatory cells from the dermis

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Similarly, activating the Nrf2/HO-1 axis to enhance cellular antioxidant gene expression can hamper ferroptosis, although the potentially excessive iron release from high HO-1 expression must be considered (128)

They may recommend adjusting the dosage, exploring different forms of B12 supplementation, or addressing underlying health issues that could be contributing to your symptoms