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In a clinical trial of more than 3,000 adults with obesity, participants who received the highest dose of orforglipron, 36 milligrams, lost 11.2% of their body weight -- about 25 pounds on average -- over more than 16 months

This article breaks down that paradox, explains why discomfort is such a powerful biological signal, and shows how intensity shapes everything from lactate metabolism to brain chemistry to long-term resilience

However, in a subset of patients, adverse symptoms related to mesh placement can develop over time

2024;44:NP279-NP306

Only patients who were referred to neuro-ophthalmology were included