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The increasing use of GLP-1s, along with the recently issued coverage guidance by the CMS, will present several important factors for plans to consider in the future

Others are unable to tolerate GLP-1s and stop due to persistent side effects

Variability in GLP-1R expression among patient populations influences delivery efficacy, motivating personalized strategies guided by artificial intelligence and digital twin modeling

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Their ability to engage in multiple organ systems through biologically conserved pathways has not only validated their initial use in glycemic control but also catalyzed their expansion into cardiovascular, renal, and metabolic domains