Moreover, HQD effectively enhances serum inflammatory factor levels, indicating promising clinical efficacy ( In vivo experiments revealed that HQD significantly inhibited Nox4/p53/Bax signalling and effectively alleviated progressive proteinuria, glomerulosclerosis and podocyte loss in DN mice ( Danggui Buxue decoction is composed of Astragali Radix and Angelicae sinensis radox in a 5:1 dosage ratio, which has the effect of tonifying Qi and generating blood, and resolving blood stasis.It has been reported that peroxisome proliferator-activated receptor- coactivator-1- (PGC-1) is a major regulator of mitochondrial biogenesis, and it participates in mitochondrial biogenesis in renal diseases by orchestrating transcriptional mechanisms
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