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The team grew these cells in the lab and screened around 1,000 different plant compounds and extracts to find what would stimulate release of appetite-suppressing hormones

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Lipid peroxidation increases membrane tension, piezo1 gating, and cation permeability to execute ferroptosis

The authors reported that in obese mice, daily AOD-9604 administration over 14 days produced significant reductions in body weight gain, decreases in adipose tissue mass, and increases in fat oxidation, with effect sizes comparable to those of full-length human growth hormone [1]