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And we believe in combination with the rest of the portfolio, that will be included and available to patients over a long period of time

BMI Standards (Commonly Used Criteria): For weight management purposes, GLP-1 medications are typically considered for individuals with: BMI of 30 or higher (obesity), OR BMI of 27 or higher with at least one weight-related comorbidity (high blood pressure, type 2 diabetes, high cholesterol, sleep apnea, etc.) These are general clinical guidelines used in FDA-approved product labeling and may inform provider decisions

Abrupt cessation often leads to rapid appetite return and weight regain

Brand-name Wegovy can cost over $1,300 per month without insurance

In preclinical hepatocyte and rodent models, the compound is studied for its effects on lipogenesis, -oxidation enzymes, and de-novo lipogenic transcription factors such as SREBP-1c and ChREBP