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The combination of L-egt and metformin related to downregulation of NF-kB/TGF-1 mRNA expression may enhance therapeutic efficacy and serve as an adjuvant therapy to alleviate renal damage in T2DM (Table 2 (Table 2)

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performed the first clinical, pilot study on antioxidants, which included 22 consecutive patients with mild or moderately severe GO treated with placebo or allopurinol (200 mg daily) plus nicotinamide (300 mg daily) for 3 months (42)

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