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Serial analyses of the metabolic profile showed consistently high HbA1c levels and body weight loss among GLP-1 RAs users

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Pre-infusion CAR T cells of long-term responders (LTR) have increased oxidative phosphorylation, fatty acid oxidation, and pentose phosphate pathway activities, higher mitochondrial mass, tighter cristae, and lower mTOR expression compared to products of short-term responders