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The results of comparing healthy controls and patients with A pathology alone with A together with tau pathology indicate that A is associated with disturbances in iron balance, as evidenced by lower NCOA4 expression, and a decrease in GPX4 antioxidant enzyme expression in the grey matter

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The disulfide bridge between Cys and Cys is essential for maintaining the peptides bioactive conformation

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Free radicals, being highly reactive molecules, can induce oxidative stress and damage vital cellular components like DNA, proteins, and lipids