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Elevated IGF-1 levels are associated with increased cancer risk in observational studies, particularly for hormone-sensitive tumors. Pollak, Nature Reviews Cancer Avoid use if you have: Personal or family history of cancer Undiagnosed growths or polyps A genetic predisposition to hormone-related cancers Diabetics and Individuals with Insulin Resistance IGF-1 directly affects glucose uptake and insulin signaling

Demidchik V, Straltsova D, Medvedev SS, Pozhvanov GA, Sokolik A, Yurin V (2014) Stress-induced electrolyte leakage: the role of K+-permeable channels and involvement in programmed cell death and metabolic adjustment

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The effects of incretins as a double-edged sword on cancer