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Of note, the arousal stimulator noradrenalin, whose concentration in brain peaks during daytime, has been shown to induce oxidative stress and apoptosis in cultured oligodendrocyte progenitors ( locus caeruleus neurons have been shown to exhibit a circadian rhythm with a maximum impulse activity during the period of vigilance (Gonzlez and Aston-Jones, 2006)

Cardiovascular (CV) events are strongly related to interleukin-6 (IL-6) and C-reactive protein (CRP), independently from the classical CV risk factors [1,2,3,4]

PMCID: PMC5501366

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