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While most people obtain B-12 from meat, eggs, and dairy, excessive intake from food and supplements has no adverse effects in healthy individuals

In a mouse model of chronic kidney disease induced by adenine, catalpol activates SIRT1 and inhibits NF-B, thereby reducing inflammation, oxidative stress, and fibrosis, lowering kidney injury markers, and preventing DNA damage and apoptosis (Zaaba et al., 2023)

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